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Traditionally, clinical data was captured using paper case report forms (CRFs) and manually digitised afterwards. Nowadays data is digitally collected in Electronic Data Capture systems (EDCs) in electronic Case Report Forms (eCRFS). Many EDCs exist, such as OpenClinica / LibreClinica, Castor EDC and REDCap and the majority of the Dutch UMCs have a site license for such tools. EDCs offer a variety of functionality, such as data entry validation, import/export functionality and monitoring [hri_edc].
Quality of the eCRF is influenced by design aspects such as visibility of data elements, dependencies, validations, etc.
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[De Novo] https://ojrd.biomedcentral.com/articles/10.1186/s13023-021-02004-y
[hri_edc] https://www.health-ri.nl/electronic-data-capture-edc-or-electronic-case-record-form-ecrf-systems
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